(2S,3R)-2-Aminododecan-3-ol, a New Antifungal Agent from the Ascidian Clavelina o blonga

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl deri...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-11, Vol.67 (11), p.1879-1881
Main Authors: Kossuga, Miriam H, MacMillan, John B, Rogers, Evan W, Molinski, Tadeusz F, Nascimento, Gislene G. F, Rocha, Rosana M, Berlinck, Roberto G. S
Format: Article
Language:English
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Summary:A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/mL and against Candida glabrata with a MIC of 30 μg/mL.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049782q