Constituents of Vittaria anguste-elongata and Their Biological Activities

Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant o...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-08, Vol.68 (8), p.1180-1184
Main Authors: Wu, Pei-Lin, Hsu, Yu-Lin, Zao, Chen-Wei, Damu, Amooru G, Wu, Tian-Shung
Format: Article
Language:English
Subjects:
acetylniduloate
acetylniduloic acid
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Biphenyl Compounds
chemical structure
coumaroylquinate
cultured cells
cytotoxicity
Drug Screening Assays, Antitumor
Ferns - chemistry
ferns and fern allies
Free Radical Scavengers - chemistry
Free Radical Scavengers - isolation & purification
Free Radical Scavengers - pharmacology
General pharmacology
human health
Humans
Inhibitory Concentration 50
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
phytochemicals
Picrates - pharmacology
plant extracts
Plants, Medicinal - chemistry
spectral analysis
Taiwan
Tumor Cells, Cultured
Vittaria
Vittaria anguste
vittariflavone
vittarilide
vittarin
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Summary:Twelve new compounds, vittarin-A (1), -B (2), -C (3), -D (4), -E (5), -F (6), 3-O-acetylniduloic acid (7), ethyl 3-O-acetylniduloate (8), methyl 4-O-coumaroylquinate (9), vittarilide-A (10), and -B (11), and vittariflavone (12), as well as 20 known compounds have been isolated from the whole plant of Vittaria anguste-elongata. The structures of these compounds were determined by spectroscopic and chemical transformation methods. 5,7-Dihydroxy-3‘,4‘,5‘-trimethoxyflavone (18) displayed moderate cytotoxicity against human lung carcinoma and central nervous system carcinoma cell lines with inhibition of 89 and 61% at a concentration of 58 μM, respectively. Vittarilide-A (10) and -B (11) and ethyl 4-O-caffeoylquinate (14) exhibited moderate DPPH radical scavenging activity with IC50 values of 91, 290, and 234 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050060o