(+)-N-Deoxymilitarinone A, a Neuritogenic Pyridone Alkaloid from the Insect Pathogenic Fungus Paecilomyces f arinosus

A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol was also identified. The structures were established by spectrosc...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-03, Vol.69 (3), p.436-438
Main Authors: Cheng, Yongxian, Schneider, Bernd, Riese, Ulrike, Schubert, Barbara, Li, Zengzhi, Hamburger, Matthias
Format: Article
Language:English
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Summary:A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol was also identified. The structures were established by spectroscopic methods, in particular with the aid of extensive NMR experiments. Compound 1 induced neurite sprouting in PC 12 cells when tested at 33 and 100 μM concentrations. A cytotoxic effect was observed in human neurons (IMR-32) at a concentration of 100 μM.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050418g