(+)-N-Deoxymilitarinone A, a Neuritogenic Pyridone Alkaloid from the Insect Pathogenic Fungus Paecilomyces f arinosus

A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol was also identified. The structures were established by spectrosc...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-03, Vol.69 (3), p.436-438
Main Authors: Cheng, Yongxian, Schneider, Bernd, Riese, Ulrike, Schubert, Barbara, Li, Zengzhi, Hamburger, Matthias
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Language:English
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cited_by cdi_FETCH-LOGICAL-a104g-542ccaa988bbf8afeed18955cafdc5ea27009421660fea11b0b00b681f30eda3
cites cdi_FETCH-LOGICAL-a104g-542ccaa988bbf8afeed18955cafdc5ea27009421660fea11b0b00b681f30eda3
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container_title Journal of natural products (Washington, D.C.)
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creator Cheng, Yongxian
Schneider, Bernd
Riese, Ulrike
Schubert, Barbara
Li, Zengzhi
Hamburger, Matthias
description A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3β,5α,6β,9α-tetraol was also identified. The structures were established by spectroscopic methods, in particular with the aid of extensive NMR experiments. Compound 1 induced neurite sprouting in PC 12 cells when tested at 33 and 100 μM concentrations. A cytotoxic effect was observed in human neurons (IMR-32) at a concentration of 100 μM.
doi_str_mv 10.1021/np050418g
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title (+)-N-Deoxymilitarinone A, a Neuritogenic Pyridone Alkaloid from the Insect Pathogenic Fungus Paecilomyces f arinosus
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