Arugosins G and H:  Prenylated Polyketides from the Marine-Derived Fungus Emericella n idulans var. a cristata

The fungus Emericella nidulans var. acristata was isolated as an endophyte from a Mediterranean green alga. Cultivation of this fungus yielded two new compounds, arugosins G (1) and H (2), together with the known metabolites 3−9. Arugosins (1−4) are benzophenone derivatives, biosynthetically related...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-07, Vol.69 (7), p.995-1000
Main Authors: Kralj, Ana, Kehraus, Stefan, Krick, Anja, Eguereva, Ekaterina, Kelter, Gerhard, Maurer, Martina, Wortmann, Andreas, Fiebig, Heinz-Herbert, König, Gabriele M
Format: Article
Language:English
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Summary:The fungus Emericella nidulans var. acristata was isolated as an endophyte from a Mediterranean green alga. Cultivation of this fungus yielded two new compounds, arugosins G (1) and H (2), together with the known metabolites 3−9. Arugosins (1−4) are benzophenone derivatives, biosynthetically related to the xanthones 5, 6, and 9. The indole alkaloid 7 displayed antitumor activity in a panel of 36 human tumor cell lines, exhibiting a mean IC50 value of 5.5 μg/mL in an in vitro survival and proliferation assay. Furthermore, compounds 3 and 4 showed moderate antitumor activity toward individual tumor cell lines. None of compounds 1−8 exhibited any immunostimulatory activity assessed as the capacity to induce cytokines in PBMCs from healthy donors.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050454f