C-26 and C-30 Apocarotenoids from Seeds of Ditaxis h eterantha with Antioxidant Activity and Protection against DNA Oxidative Damage

The hexane extracts of seeds of Ditaxis heterantha afforded two new apocarotenoids whose structures corresponded to methyl 3-oxo-12‘-apo-ε-caroten-12‘-oate (1) (heteranthin) and methyl 3β,6β-epoxy-5β-hydroxy-4,5-dihydro-8‘-apo-ε-caroten-8‘-oate (2) (ditaxin). Both compounds were evaluated for antiox...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2006-08, Vol.69 (8), p.1140-1144
Main Authors: Méndez-Robles, María D, Permady, Herry H, Jaramillo-Flores, María E, Lugo-Cervantes, Eugenia C, Cardador-Martínez, Anaberta, Canales-Aguirre, Alejandro A, López-Dellamary, Fernando, Cerda-García-Rojas, Carlos M, Tamariz, Joaquín
Format: Article
Language:English
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Summary:The hexane extracts of seeds of Ditaxis heterantha afforded two new apocarotenoids whose structures corresponded to methyl 3-oxo-12‘-apo-ε-caroten-12‘-oate (1) (heteranthin) and methyl 3β,6β-epoxy-5β-hydroxy-4,5-dihydro-8‘-apo-ε-caroten-8‘-oate (2) (ditaxin). Both compounds were evaluated for antioxidant activity and protection against DNA oxidative damage by using DPPH• free radical scavenging and Comet assays, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050489f