Chemopreventive Effects of (−)-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2014-10, Vol.77 (10), p.2312-2315
• Main Authors: Barbosa, Lilian C, Furtado, Ricardo A, Bertanha, Humberto C. C, Tomazella, Iara M, Costa, Eveline S, Bastos, Jairo K, Silva, Márcio L. Andrade e, Tavares, Denise C
• Format: Article
• Language: English
• Subjects: 1,2-Dimethylhydrazine - pharmacology; 4-Butyrolactone - analogs & derivatives; 4-Butyrolactone - chemistry; 4-Butyrolactone - pharmacology; Animals; Anticarcinogenic Agents - pharmacology; Benzodioxoles; Carcinogens - pharmacology; Colon - drug effects; Comet Assay; Dimethylhydrazines - chemistry; Dioxoles - chemistry; Dioxoles - pharmacology; DNA Damage - drug effects; Lignans - chemistry; Lignans - pharmacology; Male; Molecular Structure; Piper - chemistry; Rats; Rats, Wistar; Stereoisomerism
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np500093u

(−)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (−)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4–5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay.