Antibacterial Activity of Totarol and Its Potentiation

Antimicrobial activity of six diterpenoids isolated from the bark of Podocarpus nagi (Podocarpaceae) has been tested against twelve selected microorganisms. Totarol [1], the most abundant compound among the six, exhibited potent bactericidal activity only against Gram-positive bacteria, among which...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1992-10, Vol.55 (10), p.1436-1440
Main Authors: Kubo, Isao, Muroi, Hisae, Himejima, Masaki
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
ANTIBACTERIAL PROPERTIES
Antifungal Agents - pharmacology
ANTIMICROBIAL PROPERTIES
Bacteria - drug effects
BARK PRODUCTS
Biological and medical sciences
Diterpenes - pharmacology
DITERPENOIDE
DITERPENOIDS
DITERPENOS
Drug Synergism
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
General pharmacology
Gram-Positive Bacteria - drug effects
Medical sciences
Microbial Sensitivity Tests
Penicillin G - pharmacology
Penicillin Resistance
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PLANT EXTRACTS
Plant Extracts - pharmacology
PODOCARPUS
PODOCARPUS NAGI
PRODUIT A BASE D'ECORCE
PROPIEDADES ANTIMICROBIANAS
PROPRIETE ANTIMICROBIENNE
TROZOS DE CORTEZA
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antimicrobial activity of six diterpenoids isolated from the bark of Podocarpus nagi (Podocarpaceae) has been tested against twelve selected microorganisms. Totarol [1], the most abundant compound among the six, exhibited potent bactericidal activity only against Gram-positive bacteria, among which Propionibacterium acnes was the most sensitive bacterium. Totarol also showed strong activity against four other Gram-positive bacteria tested: Streptococcus mutans, Bacillus subtilis, Brevibacterium ammoniagenes, and Staphylococcus aureus (both penicillin-resistant and penicillin-susceptible strains). The bactericidal activity of totarol was enhanced when it was tested in combination with several other natural products. Noticeably, the activity of totarol against Sta. aureus was increased eightfold when tested in combination with 1/2MIC of anacardic acid [9]. The synergistic activity of anacardic acid caused the minimum bactericidal concentration (MBC) of totarol to be lowered from 1.56 to 0.2 micrograms/ml.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50088a008