Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis

The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol co...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1992-12, Vol.55 (12), p.1732-1740
Main Authors: Amoros, M, Simõs, C. M. O, Girre, L, Sauvager, F, Cormier, M
Format: Article
Language:English
Subjects:
Animals
ANTIVIRAL
ANTIVIRAL AGENTS
Antiviral Agents - pharmacology
ARBOLES
ARBRE
Biological and medical sciences
CELL CULTURE
Cell Survival - drug effects
CULTIVO DE CELULAS
CULTURE DE CELLULE
CYTOTOXICITY
Drug Synergism
DRUGS
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Flavonoids - pharmacology
Flavonols
General pharmacology
HERPETOVIRIDAE
Medical sciences
MEDICAMENT
MEDICAMENTOS
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PLANT EXTRACTS
PROPOLEOS
PROPOLIS
Propolis - chemistry
Propolis - pharmacology
Simplexvirus - drug effects
SINERGISMO
SYNERGIE
SYNERGISM
TOXICIDAD
TOXICITE
TOXICITY
TREES
Vero Cells
Viral Plaque Assay
VIRICIDAS
Virus Replication - drug effects
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Description
Summary:The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50090a003