Bioactive 5α-Pregnane-Type Steroidal Alkaloids from Sarcococca hookeriana

The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5α-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3−10). The structures of 1 and 2 were elucidated...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-08, Vol.71 (8), p.1481-1484
Main Authors: Devkota, Krishna P, Lenta, Bruno N, Wansi, Jean D, Choudhary, Muhammad I, Kisangau, Daniel P, Naz, Qamar, Samreen, Sewald, Norbert
Format: Article
Language:English
Subjects:
acetylcholinesterase
Bacillus subtilis
Biological and medical sciences
butyrylcholinesterase
Buxaceae
chemical structure
cholinesterase inhibitors
Enterococcus faecalis
enzyme inhibition
General pharmacology
hookerianamide
Leishmania major
Medical sciences
Micrococcus luteus
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
pregnane
Pseudomonas
Pseudomonas pallida
Sarcococca hookeriana
spectral analysis
steroid alkaloids
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Summary:The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5α-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3−10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC50 8.1−48.5 μM) and butyrylcholinesterase (IC50 0.4−4.0 μM). Compounds 1−10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.
ISSN:0163-3864
1520-6025
DOI:10.1021/np800305b