Cytotoxic Diterpenoids from Croton argyrophylloides

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2009-10, Vol.72 (10), p.1884-1887
• Main Authors: Santos, Hélcio S, Barros, Francisco W. A, Albuquerque, Maria Rose Jane R, Bandeira, Paulo N, Pessoa, Claúdia, Braz-Filho, Raimundo, Monte, Francisco J. Q, Leal-Cardoso, Jose Henrique, Lemos, Telma L. G
• Format: Article
• Language: English
• Subjects: Animals; anticarcinogenic activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Biological and medical sciences; Brazil; chemical structure; Croton; Croton - chemistry; Croton argyrophylloides; cytotoxicity; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Drug Screening Assays, Antitumor; Erythrocytes - drug effects; General pharmacology; Hemolytic Agents - chemistry; Hemolytic Agents - isolation & purification; Hemolytic Agents - pharmacology; HL-60 Cells; human diseases; human health; Humans; Medical sciences; medicinal plants; Mice; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; spectral analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np900250k

Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1−3.