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Three New Pseudodistomins, Piperidine Alkaloids from the Ascidian Pseudodistoma megalarva

Bioassay-guided fractionation of the MeOH−CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D−F (3−5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were esta...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-10, Vol.60 (10), p.986-990
Main Authors: Freyer, Alan J, Patil, Ashok D, Killmer, Lew, Troupe, Nelson, Mentzer, Mary, Carte, Brad, Faucette, Leo, Johnson, Randall K
Format: Article
Language:English
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Summary:Bioassay-guided fractionation of the MeOH−CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D−F (3−5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were established by interpretation of spectral data. Pseudodistomins B−F were found to be active in a cell-based assay for DNA damage induction, but the activity was due to an alternative mechanism.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9701438