Rubrobramide, a Cytotoxic and Phytotoxic Metabolite from Cladobotryum rubrobrunnescens

Cladobotrin (1) and rubrobramide (2) were isolated from the culture filtrate of Cladobotryum rubrobrunnescens, a mycophilic deuteriomycete. Rubrobramide (2), possessing a unique oxidized tricyclic system, is a new compound structurally related to flavipucine (3), which also is produced by the fungus...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1998-04, Vol.61 (4), p.501-502
Main Authors: Wagner, Christian, Anke, Heidrun, Sterner, Olov
Format: Article
Language:English
Subjects:
AGARICALES
ALEMANIA
ALLEMAGNE
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
CLADOBOTRIN
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CYTOTOXIC COMPOUNDS
DEUTEROMYCOTINA
EPIFITAS
EPIPHYTE
EPIPHYTES
ESPECTROMETRIA
ESTRUCTURA QUIMICA
FILTRACION
FILTRATION
FITOTOXINAS
FLAVIPUCINE
Fundamental and applied biological sciences. Psychology
General aspects
GERMANY
INOCYBE
MELOIDOGYNE INCOGNITA
METABOLITE
METABOLITES
METABOLITOS
Microbiology
MICROORGANISME
MICROORGANISMOS
MICROORGANISMS
MYCOPHILIC FUNGI
NEMATICIDAL PROPERTIES
NEMATICIDES
NEMATOCIDAS
NEMATOCIDE
PHYTOTOXINE
PHYTOTOXINS
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STRUCTURE CHIMIQUE
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
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Summary:Cladobotrin (1) and rubrobramide (2) were isolated from the culture filtrate of Cladobotryum rubrobrunnescens, a mycophilic deuteriomycete. Rubrobramide (2), possessing a unique oxidized tricyclic system, is a new compound structurally related to flavipucine (3), which also is produced by the fungus. The structure of 2 was determined by spectroscopic methods. Cladobotrin (1) exhibited weak nematicidal activity toward Meloidogyne incognita, while 2 showed weak cytotoxic and phytotoxic activities.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9704967