Annonaceous Acetogenins:  Recent Progress

The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-03, Vol.62 (3), p.504-540
Main Authors: Alali, Feras Q, Liu, Xiao-Xi, McLaughlin, Jerry L
Format: Article
Language:English
Subjects:
acetogenins
Animals
Annonaceae
antineoplastic agents
Antineoplastic Agents, Phytogenic - biosynthesis
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
biochemical pathways
Biological and medical sciences
biosynthesis
checklists
chemical constituents of plants
chemical reactions
chemical structure
disease resistance
Drug Resistance, Microbial
Drug Resistance, Multiple
Furans - chemistry
Furans - metabolism
Furans - pharmacology
General pharmacology
Humans
Lactones - chemistry
Lactones - metabolism
Lactones - pharmacology
literature reviews
Medical sciences
medicinal plants
pest resistance
Pesticides - chemistry
Pesticides - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
spectral analysis
structure-activity relationships
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Summary:The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.
ISSN:0163-3864
1520-6025
DOI:10.1021/np980406d