Two Auronols from Pseudolarix a mabilis

Two new auronols, amaronols A (1) and B (2), were isolated from the bark of Pseudolarix amabilis, along with pseudolaric acid B (3), pseudolaric acid C (4), demethoxydeacetoxy-pseudolaric acid B (5), pseudolaric acid B-β-d-glucoside (6), pseudolaric acid A-β-d-glucoside (7), and myricetin (8). The s...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-05, Vol.62 (5), p.767-769
Main Authors: Li, Xing-Cong, ElSohly, Hala N, Nimrod, Alison C, Clark, Alice M
Format: Article
Language:English
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Summary:Two new auronols, amaronols A (1) and B (2), were isolated from the bark of Pseudolarix amabilis, along with pseudolaric acid B (3), pseudolaric acid C (4), demethoxydeacetoxy-pseudolaric acid B (5), pseudolaric acid B-β-d-glucoside (6), pseudolaric acid A-β-d-glucoside (7), and myricetin (8). The structures of amaronols A and B were established by spectral data interpretation as 2,4,6-trihydroxy-2-[(3‘,4‘,5‘-trihydroxyphenyl) methyl]-3(2H)-benzofuranone and 2,4,6-trihydroxy-2-[(3‘,5‘-dihydroxy-4‘-methoxyphenyl) methyl]-3(2H)-benzofuranone, respectively. Antimicrobial testing results of the eight compounds indicated that only pseudolaric acid B was active against Candida albicans (MIC, 3.125 μg/mL; MFC, 6.25 μg/mL), while myricetin was marginally active against Trichophyton mentagrophytes (MIC, 50 μg/mL).
ISSN:0163-3864
1520-6025
DOI:10.1021/np980469w