Bis-5-alkylresorcinols from Panopsis r ubescens that Inhibit DNA Polymerase β

Bioassay-guided fractionation of Panopsis rubescens, using an assay to detect DNA polymerase β inhibition, led to the isolation of two new bis-5-alkylresorcinols (1 and 2), in addition to one known bis-5-alkylresorcinol (3). The structures of 1−3 were established as 1,3-dihydroxy-5-[14‘-(3‘ ‘,5‘ ‘-d...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-03, Vol.62 (3), p.477-480
Main Authors: Deng, Jing-Zhen, Starck, Shelley R, Hecht, Sidney M
Format: Article
Language:English
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Summary:Bioassay-guided fractionation of Panopsis rubescens, using an assay to detect DNA polymerase β inhibition, led to the isolation of two new bis-5-alkylresorcinols (1 and 2), in addition to one known bis-5-alkylresorcinol (3). The structures of 1−3 were established as 1,3-dihydroxy-5-[14‘-(3‘ ‘,5‘ ‘-dihydroxyphenyl)-cis-4‘-tetradecenyl]benzene (1), 1,3-dihydroxy-5-[14‘-(3‘ ‘,5‘ ‘-dihydroxyphenyl)-cis-7‘-tetradecenyl]benzene (2), and 1,3-dihydroxy-5-[14‘-(3‘ ‘,5‘ ‘-dihydroxyphenyl)tetradecenyl]benzene (3), respectively, by spectroscopic and chemical analyses. Compounds 1−3 exhibited potent inhibition of calf thymus DNA polymerase β, with IC50 values of 7.5, 6.5, and 5.8 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np980522g