Sesquiterpene Alkaloids from Tripterygium h ypoglaucum and Tripterygium w ilfordii:  A New Class of Potent Anti-HIV Agents

Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1 − 5 w...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2000-03, Vol.63 (3), p.357-361
Main Authors: Duan, Hongquan, Takaishi, Yoshihisa, Imakura, Yasuhiro, Jia, Yongfong, Li, Duan, Cosentino, L. Mark, Lee, Kuo-Hsiung
Format: Article
Language:English
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Summary:Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1 − 5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC50 value of 1000.
ISSN:0163-3864
1520-6025
DOI:10.1021/np990281s