Alkaloids from Delphinium staphisagria

Three new diterpenoid alkaloids, isoazitine (1), 19-oxodihydroatisine (2), and 22-O-acetyl-19-oxodihydroatisine (3), and eight known alkaloidsazitine (4), dihydroatisine (5), delphinine, neoline, bullatine C (14-acetylneoline), chasmanine, 14-acetylchasmanine, and the quaternary base atisinium chlo...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2000-08, Vol.63 (8), p.1136-1139
Main Authors: Díaz, Jesús G, Ruiz, Juan García, de la Fuente, Gabriel
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Biological and medical sciences
Chromatography, Liquid
Chromatography, Thin Layer
Diterpenes
Gas Chromatography-Mass Spectrometry
General pharmacology
Medical sciences
Morocco
Optical Rotation
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Toxic - chemistry
Spectrophotometry, Infrared
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Summary:Three new diterpenoid alkaloids, isoazitine (1), 19-oxodihydroatisine (2), and 22-O-acetyl-19-oxodihydroatisine (3), and eight known alkaloidsazitine (4), dihydroatisine (5), delphinine, neoline, bullatine C (14-acetylneoline), chasmanine, 14-acetylchasmanine, and the quaternary base atisinium chloride (7)were isolated from the aerial parts of Delphinium staphisagria. Structures of the new alkaloids were established mainly by 1D and 2D NMR spectroscopy, including 1H COSY, HMQC, HMBC, and ROESY. The 1H and 13C NMR data for alkaloids 4 and 5 are also reported.
ISSN:0163-3864
1520-6025
DOI:10.1021/np990453l