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Facile Synthesis of O 6-Alkyl-, O 6-Aryl-, and Diaminopurine Nucleosides from 2‘-Deoxyguanosine
The 3‘,5‘-bis-O-TBDMS derivative of 2‘-deoxyguanosine can be converted to its O 6-alkyl and O 6-aryl ethers as well as to N 6-substituted diaminopurine nucleosides in two simple steps. Also described is a novel, nonaqueous, one-step O 6-desulfonylation method that leads to deprotection of the carbon...
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| Published in: | Organic letters 2000-04, Vol.2 (7), p.927-930 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a189t-393b628b5830af826a4e7a133ace68995777fcb41e1b0f54199f3e232d56fd333 |
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| cites | cdi_FETCH-LOGICAL-a189t-393b628b5830af826a4e7a133ace68995777fcb41e1b0f54199f3e232d56fd333 |
| container_end_page | 930 |
| container_issue | 7 |
| container_start_page | 927 |
| container_title | Organic letters |
| container_volume | 2 |
| creator | Lakshman, Mahesh K Ngassa, Felix N Keeler, John C Dinh, Yen Q. V Hilmer, John H Russon, Larry M |
| description | The 3‘,5‘-bis-O-TBDMS derivative of 2‘-deoxyguanosine can be converted to its O 6-alkyl and O 6-aryl ethers as well as to N 6-substituted diaminopurine nucleosides in two simple steps. Also described is a novel, nonaqueous, one-step O 6-desulfonylation method that leads to deprotection of the carbonyl moiety of 2‘-deoxyguanosine. |
| doi_str_mv | 10.1021/ol005564m |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2000-04, Vol.2 (7), p.927-930 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_ol005564m |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| title | Facile Synthesis of O 6-Alkyl-, O 6-Aryl-, and Diaminopurine Nucleosides from 2‘-Deoxyguanosine |
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