Progress toward the Total Synthesis of Ingenol:  Construction of the Complete Carbocyclic Skeleton

The complete carbocyclic skeleton of ingenol is assembled via a route that employs ring-closing metathesis (RCM) to close the strained “inside-outside” BC ring system (i.e., 24 → 25).

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Bibliographic Details
Published in:Organic letters 2001-05, Vol.3 (10), p.1563-1566
Main Authors: Tang, Haifeng, Yusuff, Naeem, Wood, John L
Format: Article
Language:English
Subjects:
Anti-HIV Agents - chemical synthesis
Antineoplastic Agents - chemical synthesis
Diterpenes - chemical synthesis
Irritants - chemical synthesis
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Description
Summary:The complete carbocyclic skeleton of ingenol is assembled via a route that employs ring-closing metathesis (RCM) to close the strained “inside-outside” BC ring system (i.e., 24 → 25).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol015855a