Novel Dolabellane-Type Diterpene Alkaloids with Lipid Metabolism Promoting Activities from the Seeds of Nigella s ativa

Four new dolabellane-type diterpene alkaloids, nigellamines A1 (1), A2 (2), B1 (3), and B2 (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A1 (1), B1 (3), and B2 (4) were found to...

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Bibliographic Details
Published in:Organic letters 2004-03, Vol.6 (6), p.869-872
Main Authors: Morikawa, Toshio, Xu, Fengming, Kashima, Yousuke, Matsuda, Hisashi, Ninomiya, Kiyofumi, Yoshikawa, Masayuki
Format: Article
Language:English
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Summary:Four new dolabellane-type diterpene alkaloids, nigellamines A1 (1), A2 (2), B1 (3), and B2 (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A1 (1), B1 (3), and B2 (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-α agonist, clofibrate.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol036239c