A Ring-Closing Yne-Carbonyl Metathesis of Ynamides

An acid-catalyzed ring-closing ynamide-carbonyl metathesis is described here. This hetero RCM methodology is applicable to the construction of carbocycles as well as heterocycles such as chromenes, quinolizidines, indolizidines, and pyrrolizidines.

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Bibliographic Details
Published in:Organic letters 2006-01, Vol.8 (2), p.231-234
Main Authors: Kurtz, Kimberly C. M, Hsung, Richard P, Zhang, Yanshi
Format: Article
Language:English
Subjects:
Amides - chemical synthesis
Amides - chemistry
Catalysis
Cyclization
Heterocyclic Compounds, 2-Ring - chemical synthesis
Heterocyclic Compounds, 2-Ring - chemistry
Molecular Structure
Oxidation-Reduction
Pyrrolizidine Alkaloids - chemical synthesis
Pyrrolizidine Alkaloids - chemistry
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Description
Summary:An acid-catalyzed ring-closing ynamide-carbonyl metathesis is described here. This hetero RCM methodology is applicable to the construction of carbocycles as well as heterocycles such as chromenes, quinolizidines, indolizidines, and pyrrolizidines.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052487s