Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of Diphenylsulfide

A Pd/C-catalyzed chemoselective hydrogenation using diphenylsulfide as a catalyst poison has been developed. This methodology selectively hydrogenates olefin and acetylene functionalities without hydrogenolysis of aromatic carbonyls and halogens, benzyl esters, and N-Cbz protective groups.

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Bibliographic Details
Published in:Organic letters 2006-07, Vol.8 (15), p.3279-3281
Main Authors: Mori, Akinori, Miyakawa, Yumi, Ohashi, Eri, Haga, Tomoko, Maegawa, Tomohiro, Sajiki, Hironao
Format: Article
Language:English
Subjects:
Acetylene - chemistry
Alkenes - chemistry
Catalysis
Combinatorial Chemistry Techniques
Hydrogenation
Oxidation-Reduction
Palladium - chemistry
Sulfides - chemistry
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Description
Summary:A Pd/C-catalyzed chemoselective hydrogenation using diphenylsulfide as a catalyst poison has been developed. This methodology selectively hydrogenates olefin and acetylene functionalities without hydrogenolysis of aromatic carbonyls and halogens, benzyl esters, and N-Cbz protective groups.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol061147j