Pd-Catalyzed Asymmetric Allylic Alkylation of Indoles and Pyrroles by Chiral Alkene-Phosphine Ligands

A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to...

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Bibliographic Details
Published in:Organic letters 2011-05, Vol.13 (9), p.2164-2167
Main Authors: Cao, Ziping, Liu, Yilin, Liu, Zhaoqun, Feng, Xiangqing, Zhuang, Minyang, Du, Haifeng
Format: Article
Language:English
Subjects:
Alkenes - chemistry
Alkylation
Catalysis
Indoles - chemistry
Ligands
Molecular Structure
Palladium - chemistry
Phosphines - chemistry
Pyrroles - chemistry
Stereoisomerism
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Summary:A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to excellent ee’s.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200602x