Addition of Amines to Nitriles Catalyzed by Ytterbium Amides:  An Efficient One-Step Synthesis of Monosubstituted N-Arylamidines

A one-step synthesis of monosubstituted N-arylamidinates via addition of amines to nitriles catalyzed by ytterbium amides is reported. The reactions with various substrates give the products in good to excellent yields with 5 mol % ytterbium at 100 °C under solvent-free conditions.

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Bibliographic Details
Published in:Organic letters 2008-02, Vol.10 (3), p.445-448
Main Authors: Wang, Junfeng, Xu, Fan, Cai, Tao, Shen, Qi
Format: Article
Language:English
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Summary:A one-step synthesis of monosubstituted N-arylamidinates via addition of amines to nitriles catalyzed by ytterbium amides is reported. The reactions with various substrates give the products in good to excellent yields with 5 mol % ytterbium at 100 °C under solvent-free conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol702739c