Horner−Emmons Synthesis with Minimal Purification Using ROMPGEL:  A Novel High-Loading Matrix for Supported Reagents

The synthesis and use of two novel high-loading Horner−Emmons ring-opening metathesis polymers are described. α,β-Unsaturated ethyl esters (E:Z > 99:1) and α,β-unsaturated nitriles (E:Z > 70:30) are obtained in excellent yields and purities from aldehydes with minimal purification.

Saved in:
Bibliographic Details
Published in:Organic letters 1999-08, Vol.1 (4), p.579-582
Main Authors: Barrett, Anthony G. M, Cramp, Susan M, Roberts, Richard S, Zecri, Frederic J
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and use of two novel high-loading Horner−Emmons ring-opening metathesis polymers are described. α,β-Unsaturated ethyl esters (E:Z > 99:1) and α,β-unsaturated nitriles (E:Z > 70:30) are obtained in excellent yields and purities from aldehydes with minimal purification.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol990694k