Reactions of Pd(PPh3)4 with 3‘,5‘-Di-O-acetylthymidine:  Oxidative Addition of Pd(PPh3)4 on Thymidine N3 and C4 Atoms

Oxidative addition reactions of Pd(PPh3)4 on the pyrimidine nucleosides 3‘,5‘-di-O-acetylthymidine and 3‘,5‘-di-O-acetyl-4-chlorothymidine and on the nucleobase 1-methylthymine have been investigated. N3 and C4 metal coordinated complexes 3 and 7 were isolated and characterized by spectroscopic tech...

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Published in:Organometallics 2005-07, Vol.24 (14), p.3401-3406
Main Authors: Romanelli, Alessandra, Iacovino, Rosa, Piccialli, Gennaro, Ruffo, Francesco, De Napoli, Lorenzo, Pedone, Carlo, Di Blasio, Benedetto, Messere, Anna
Format: Article
Language:English
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Summary:Oxidative addition reactions of Pd(PPh3)4 on the pyrimidine nucleosides 3‘,5‘-di-O-acetylthymidine and 3‘,5‘-di-O-acetyl-4-chlorothymidine and on the nucleobase 1-methylthymine have been investigated. N3 and C4 metal coordinated complexes 3 and 7 were isolated and characterized by spectroscopic techniques. Moreover, the crystal structure of the trans-[PdCl(1-methyl thymine)(PPh3)2]·H2O (4) is reported.
ISSN:0276-7333
1520-6041
DOI:10.1021/om050058s