Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes

Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activ...

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Bibliographic Details
Published in:Organometallics 2013-05, Vol.32 (10), p.3012-3017
Main Authors: Mavrynsky, Denys, Rahkila, Jani, Bandarra, Daniel, Martins, Soraia, Meireles, Margarida, Calhorda, Maria José, Kovács, Ida J, Zupkó, István, Hänninen, Mikko M, Leino, Reko
Format: Article
Language:English
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Summary:Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1–S transiton as evidenced by flow cytometry.
ISSN:0276-7333
1520-6041
DOI:10.1021/om400234p