Synthesis of Oxindole-Based Bioorganometallic Kinase Inhibitors Incorporating One or More Ferrocene Groups

A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by mole...

Full description

Saved in:
Bibliographic Details
Published in:Organometallics 2013-10, Vol.32 (20), p.5818-5825
Main Authors: Amin, Jahangir, Chuckowree, Irina S, Wang, Minghua, Tizzard, Graham J, Coles, Simon J, Spencer, John
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.
ISSN:0276-7333
1520-6041
DOI:10.1021/om400359m