Synthesis of 4‑Silapiperidine Building Blocks with N–H Groups Using the Staudinger Reaction

4-Silapiperidines are important skeletons for drug design. In this context, a novel acid-free method for the synthesis of 4-silapiperidine building blocks with N–H groups has been developed, using the Staudinger reaction as the key step. As a proof of principle, the model compounds 13 and 14 were sy...

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Published in:Organometallics 2013-12, Vol.32 (23), p.7181-7185
Main Authors: Fischer, Markus, Tacke, Reinhold
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Language:English
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description 4-Silapiperidines are important skeletons for drug design. In this context, a novel acid-free method for the synthesis of 4-silapiperidine building blocks with N–H groups has been developed, using the Staudinger reaction as the key step. As a proof of principle, the model compounds 13 and 14 were synthesized, starting from Ph2SiCl2 and MeSi(OMe)3, respectively.
doi_str_mv 10.1021/om400873w
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title Synthesis of 4‑Silapiperidine Building Blocks with N–H Groups Using the Staudinger Reaction
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