Sila-rhubafuran and Derivatives: Synthesis and Olfactory Characterization of Novel Silicon-Containing Odorants

Sila-rhubafuran (1b), a silicon analogue of the grapefruit odorant rhubafuran (1a), was synthesized and isolated as a 1:1 mixture of two racemic diastereomers. In addition, the structurally related racemic C/Si pairs 2a/2b and 3a/3b were prepared. To get information about structure–odor relationship...

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Bibliographic Details
Published in:Organometallics 2014-01, Vol.33 (1), p.338-346
Main Authors: Förster, Bettina, Bertermann, Rüdiger, Kraft, Philip, Tacke, Reinhold
Format: Article
Language:English
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Summary:Sila-rhubafuran (1b), a silicon analogue of the grapefruit odorant rhubafuran (1a), was synthesized and isolated as a 1:1 mixture of two racemic diastereomers. In addition, the structurally related racemic C/Si pairs 2a/2b and 3a/3b were prepared. To get information about structure–odor relationships in the domain of grapefruit odorants, the C/Si pairs 1a/1b, 2a/2b, and 3a/3b were studied for their olfactory properties.
ISSN:0276-7333
1520-6041
DOI:10.1021/om401070c