The Synthesis of a GH-Releasing Compound NNC 26-1089

The synthesis of trimethylhydrazine hydrochloride provides a stable and safe-to-handle reactant for multigram-scale synthesis making the preparation of the tripeptidelike Novo Nordisk growth hormone secretagogue NNC 26-1089 in multigram scale feasible. NNC 26-1089 was synthesised over seven steps in...

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Bibliographic Details
Published in:Organic process research & development 2002-07, Vol.6 (4), p.367-373
Main Authors: Andersen, Peter, Ankersen, Michael, Jessen, Claus Ulrich, Lehman, Søren Vig
Format: Article
Language:English
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Summary:The synthesis of trimethylhydrazine hydrochloride provides a stable and safe-to-handle reactant for multigram-scale synthesis making the preparation of the tripeptidelike Novo Nordisk growth hormone secretagogue NNC 26-1089 in multigram scale feasible. NNC 26-1089 was synthesised over seven steps in an overall yield of 33%, with a stereoisomeric purity of more than 99% measured by chiral capillary electrophoresis (CE).
ISSN:1083-6160
1520-586X
DOI:10.1021/op0200118