Investigation of Practical Routes for the Kilogram-Scale Production of cis-3-Methylamino-4-methylpiperidines

Two routes for the synthesis of cis-N-protected-3-methylamino-4-methylpiperidine (3) were examined:  a route hinging on the electrochemical oxidation of carbamate 1 to install a ketone at the 3 position of the piperidine followed by reductive amination (disconnection A), and a route involving the hy...

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Bibliographic Details
Published in:Organic process research & development 2005-01, Vol.9 (1), p.51-56
Main Authors: Cai, Weiling, Colony, James L, Frost, Heather, Hudspeth, James P, Kendall, Peter M, Krishnan, Ashwin M, Makowski, Teresa, Mazur, Duane J, Phillips, James, Ripin, David H. Brown, Ruggeri, Sally Gut, Stearns, Jay F, White, Timothy D
Format: Article
Language:English
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Summary:Two routes for the synthesis of cis-N-protected-3-methylamino-4-methylpiperidine (3) were examined:  a route hinging on the electrochemical oxidation of carbamate 1 to install a ketone at the 3 position of the piperidine followed by reductive amination (disconnection A), and a route involving the hydrogenation of an appropriately functionalized pyridine (disconnection B). While both routes to the desired compound were ultimately successful, the pyridine hydrogenation approach proved to be more amenable to kilogram-scale preparations due to the crystallinity and purity of intermediates in that route.
ISSN:1083-6160
1520-586X
DOI:10.1021/op049808k