Novel Innovation Systems for a Cellular Approach to Continuous Process Chemistry from Discovery to Market

Continuous processing of liquid/liquid synthesis and microreaction technology are shown to reduce the cost of process development and manufacturing of active pharmaceutical ingredients and other functional molecules on a commercial scale. Combinatorial synthesis systems for continuous chemistry are...

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Bibliographic Details
Published in:Organic process research & development 2004-05, Vol.8 (3), p.440-454
Main Authors: Schwalbe, Thomas, Autze, Volker, Hohmann, Michael, Stirner, Wolfgang
Format: Article
Language:English
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Summary:Continuous processing of liquid/liquid synthesis and microreaction technology are shown to reduce the cost of process development and manufacturing of active pharmaceutical ingredients and other functional molecules on a commercial scale. Combinatorial synthesis systems for continuous chemistry are introduced, and their applications are described. Reactions within these systems scale seamlessly in standardized commercial continuous synthesis equipment allowing rapid access to kilogram quantities of advanced intermediates. Chemical and process development within such systems are illustrated by a case study of a continuous multistep process. Additionally, another case study shows the benefit of microreaction technology in the manufacture of high value added functional chemicals.
ISSN:1083-6160
1520-586X
DOI:10.1021/op049970n