A Versatile Lab to Pilot Scale Continuous Reaction System for Supercritical Fluid Processing

A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature,...

Full description

Saved in:
Bibliographic Details
Published in:Organic process research & development 2011-11, Vol.15 (6), p.1275-1280
Main Authors: Hintermair, Ulrich, Roosen, Christoph, Kaever, Markus, Kronenberg, Horst, Thelen, Ralf, Aey, Stefan, Leitner, Walter, Greiner, Lasse
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature, and composition (p, T, x) can be accurately controlled over a wide flow range. The setup is completely automated by the help of computerised control and features a view cell for inline phase behavior observation. Coupling to supercritical fluid chromatography permits sampling under process conditions for reaction monitoring. Potential applications include continuous flow synthesis and catalysis, extractions, and other operations demanding controlled application of compressible gases. Highly efficient continuous flow asymmetric hydrogenation catalysis with integrated product separation is demonstrated.
ISSN:1083-6160
1520-586X
DOI:10.1021/op200053w