A Versatile Lab to Pilot Scale Continuous Reaction System for Supercritical Fluid Processing

A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature,...

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Published in:Organic process research & development 2011-11, Vol.15 (6), p.1275-1280
Main Authors: Hintermair, Ulrich, Roosen, Christoph, Kaever, Markus, Kronenberg, Horst, Thelen, Ralf, Aey, Stefan, Leitner, Walter, Greiner, Lasse
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cited_by cdi_FETCH-LOGICAL-a259t-b3a75d9aa36092d69994aff79707f370a5f0f00a33a1291b8337fe10a770d6473
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container_end_page 1280
container_issue 6
container_start_page 1275
container_title Organic process research & development
container_volume 15
creator Hintermair, Ulrich
Roosen, Christoph
Kaever, Markus
Kronenberg, Horst
Thelen, Ralf
Aey, Stefan
Leitner, Walter
Greiner, Lasse
description A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature, and composition (p, T, x) can be accurately controlled over a wide flow range. The setup is completely automated by the help of computerised control and features a view cell for inline phase behavior observation. Coupling to supercritical fluid chromatography permits sampling under process conditions for reaction monitoring. Potential applications include continuous flow synthesis and catalysis, extractions, and other operations demanding controlled application of compressible gases. Highly efficient continuous flow asymmetric hydrogenation catalysis with integrated product separation is demonstrated.
doi_str_mv 10.1021/op200053w
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title A Versatile Lab to Pilot Scale Continuous Reaction System for Supercritical Fluid Processing
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