A Robust, Streamlined Approach to Bosutinib Monohydrate

This article describes a systematic approach used to streamline the process for the isolation of bosutinib monohydrate, a promiscuous solvate former. A thorough understanding of the complex solid form landscape was garnered, and this knowledge was used to develop a process that routinely delivered t...

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Bibliographic Details
Published in:Organic process research & development 2013-03, Vol.17 (3), p.500-504
Main Authors: Withbroe, Gregory J, Seadeek, Chris, Girard, Kevin P, Guinness, Steven M, Vanderplas, Brian C, Vaidyanathan, Rajappa
Format: Article
Language:English
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Summary:This article describes a systematic approach used to streamline the process for the isolation of bosutinib monohydrate, a promiscuous solvate former. A thorough understanding of the complex solid form landscape was garnered, and this knowledge was used to develop a process that routinely delivered the correct solid form and excellent purity at the end of the last bond-formation step, without the need for additional recrystallization and/or solid form conversion steps.
ISSN:1083-6160
1520-586X
DOI:10.1021/op300087r