Improved Procedure for Preparation of Abiraterone Acetate

An improved procedure for the preparation of abiraterone acetate is described. The present process highlights reduced reaction time, isolation with acid–base treatment without involving column chromatography, multiple crystallization and is amenable to large-scale synthesis.

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Bibliographic Details
Published in:Organic process research & development 2014-04, Vol.18 (4), p.555-558
Main Authors: Madhra, Mukesh Kumar, Sriram, Hari Mohan, Inamdar, Murad, Sharma, Mukesh Kumar, Prasad, Mohan, Joseph, Sony
Format: Article
Language:English
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Description
Summary:An improved procedure for the preparation of abiraterone acetate is described. The present process highlights reduced reaction time, isolation with acid–base treatment without involving column chromatography, multiple crystallization and is amenable to large-scale synthesis.
ISSN:1083-6160
1520-586X
DOI:10.1021/op500044p