Commercial Synthesis of Azilsartan Kamedoxomil: An Angiotensin II Receptor Blocker

A commercially viable process for the preparation of azilsartan kamedoxomil, an angiotensin II receptor blocker, has been developed. The present work describes the novel synthesis of azilsartan medoxomil from amidoxime methyl ester. The present work also describes the improved synthesis of amidoxime...

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Bibliographic Details
Published in:Organic process research & development 2015-04, Vol.19 (4), p.514-519
Main Authors: Garaga, Srinivas, Misra, Nimesh C, Raghava Reddy, Ambati V, Prabahar, Koilpillai Joseph, Takshinamoorthy, Chandiran, Sanasi, Paul Douglas, Babu, Korupolu Raghu
Format: Article
Language:English
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Summary:A commercially viable process for the preparation of azilsartan kamedoxomil, an angiotensin II receptor blocker, has been developed. The present work describes the novel synthesis of azilsartan medoxomil from amidoxime methyl ester. The present work also describes the improved synthesis of amidoxime methyl ester and azilsartan kamedoxomil. This process features a high overall yield (36%) with 99.52% HPLC purity.
ISSN:1083-6160
1520-586X
DOI:10.1021/op500357r