An Improved Synthesis of Rimonabant: Anti-Obesity Drug

A novel, cost-effective, and efficient process was developed for the large-scale synthesis of Rimonabant 1, an anti-obesity drug. The process involves the conversion of 4-chloro propiophenone 2 to cyclized acid 6 as a key intermediate that afforded Rimonabant 1 in good yield.

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Bibliographic Details
Published in:Organic process research & development 2007-09, Vol.11 (5), p.910-912
Main Authors: Kotagiri, Vijay Kumar, Suthrapu, Sashikanth, Mukunda Reddy, Jambula, Prasad Rao, Chitneni, Bollugoddu, Vijaybhaskar, Bhattacharya, Apurba, Bandichhor, Rakeshwar
Format: Article
Language:English
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Summary:A novel, cost-effective, and efficient process was developed for the large-scale synthesis of Rimonabant 1, an anti-obesity drug. The process involves the conversion of 4-chloro propiophenone 2 to cyclized acid 6 as a key intermediate that afforded Rimonabant 1 in good yield.
ISSN:1083-6160
1520-586X
DOI:10.1021/op700110b