Manufacture of High-Purity Meloxicam via Its Novel Potassium Salt Monohydrate

An improved procedure for the manufacture of 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (meloxicam) is described. The key intermediate of this protocol is the new potassium salt monohydrate of meloxicam, which makes possible the efficient removal...

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Bibliographic Details
Published in:Organic process research & development 2009-05, Vol.13 (3), p.567-572
Main Authors: Mezei, Tibor, Mesterházy, Norbert, Bakó, Tibor, Porcs-Makkay, Márta, Simig, Gyula, Volk, Balázs
Format: Article
Language:English
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Summary:An improved procedure for the manufacture of 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (meloxicam) is described. The key intermediate of this protocol is the new potassium salt monohydrate of meloxicam, which makes possible the efficient removal of impurities, resulting in an environmentally friendly manufacturing process of the high-purity (>99.90%) drug substance.
ISSN:1083-6160
1520-586X
DOI:10.1021/op900031h