PPARα and PPARγ Regulation of Liver and Adipose Proteins in Obese and Dyslipidemic Rodents

Zucker fatty rats and ob/ob mice are both frequently used hyperlipidemic and insulin-resistant spontaneous genetic models of obesity. We used them to study the effect of PPAR agonists on the protein-expression level in liver and white adipose tissue. PPARα-agonist treatments of the rats resulted in...

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Bibliographic Details
Published in:Journal of proteome research 2006-08, Vol.5 (8), p.1850-1859
Main Authors: Lanne, Boel, Dahllöf, Björn, Lindahl, Charlotta, Ebefors, Kerstin, Kanmert, Ida, von Bahr, Helena, Miliotis, Tasso, Nyström, Ann-Christin, Arnerup, Gunnel, Paulsons, Ivar, Kerb, Santy, Oakes, Nick
Format: Article
Language:English
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Summary:Zucker fatty rats and ob/ob mice are both frequently used hyperlipidemic and insulin-resistant spontaneous genetic models of obesity. We used them to study the effect of PPAR agonists on the protein-expression level in liver and white adipose tissue. PPARα-agonist treatments of the rats resulted in that 27% of the quantified hepatic proteins were altered; implicating pronounced peroxisome proliferation and increase in capacity for β-oxidation of fatty acids although no correction of plasma triglycerides were obtained. On treatment with PPARγ agonists, adipose proteins were regulated to a much larger extent in the rats compared to mice, 18% and 2%, respectively. Keywords: proteomic • hyperlipidemic • ob/ob mice • Zucker rats • peroxisome proliferator-activated receptor • insulin resistance • rosiglitazone • darglitazone • WY14,643
ISSN:1535-3893
1535-3907
DOI:10.1021/pr060004o