Differential Mass Spectrometry of Rat Plasma Reveals Proteins That Are Responsive to 17β-Estradiol and a Selective Estrogen Receptor Modulator PPT

Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) α and β. To identify potential ER biomarkers, we profiled the rat plasma glycoproteome after treatment with vehicle or 17β-estradiol (E2) or an ERα-selective agonist PPT by...

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Bibliographic Details
Published in:Journal of proteome research 2008-10, Vol.7 (10), p.4373-4383
Main Authors: Zhao, Xuemei, Deyanova, Ekaterina G, Lubbers, Laura S, Zafian, Pete, Li, Jenny J, Liaw, Andy, Song, Qinghua, Du, Yi, Settlage, Robert E, Hickey, Gerry J, Yates, Nathan A, Hendrickson, Ronald C
Format: Article
Language:English
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Summary:Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) α and β. To identify potential ER biomarkers, we profiled the rat plasma glycoproteome after treatment with vehicle or 17β-estradiol (E2) or an ERα-selective agonist PPT by differential mass spectrometry. Our comparative proteomic experiment identifies novel E2- and PPT-responsive proteins, such as serine protease inhibitor family members.
ISSN:1535-3893
1535-3907
DOI:10.1021/pr800309z