Effect of the Interaction between Chelating Agents on their Fungitoxicity

THE role of chelation in the mechanism of action of 8-hydroxyquinoline (‘oxine’) against fungi has been reviewed by Horsfall 1 and Hollingshead 2 . The increased bactericidal and fungicidal activity of this compound in the presence of Cu 2+ has been ascribed to the rapid penetration of the cell wall...

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Bibliographic Details
Published in:Nature (London) 1957-03, Vol.179 (4558), p.539-539
Main Authors: BYRDE, R. J. W, WOODCOCK, D
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:THE role of chelation in the mechanism of action of 8-hydroxyquinoline (‘oxine’) against fungi has been reviewed by Horsfall 1 and Hollingshead 2 . The increased bactericidal and fungicidal activity of this compound in the presence of Cu 2+ has been ascribed to the rapid penetration of the cell wall by the highly lipophilic 1 : 2 copper: oxine complex 3,4 , which may dissociate within the cell to a more toxic substance or substances.
ISSN:0028-0836
1476-4687
DOI:10.1038/179539a0