Experimental Evidence for an Allergic Basis for Granuloma Formation in Man

GRANULOMA formation is one of the significant reaction patterns of the body in disease. Characterized by tubercles of closely packed epithelioid cells, granulomas are the basic alteration in such chronic diseases as tuberculosis, leprosy, syphilis, sarcoidosis, deep fungus infections and in reaction...

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Bibliographic Details
Published in:Nature (London) 1957-11, Vol.180 (4594), p.1060-1061
Main Authors: SHELLEY, WALTER B, HURLEY, HARRY J
Format: Article
Language:English
Subjects:
Deodorants - adverse effects
Granuloma
Humanities and Social Sciences
Humans
letter
Male
multidisciplinary
Science
Science (multidisciplinary)
Zirconium - pharmacology
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Summary:GRANULOMA formation is one of the significant reaction patterns of the body in disease. Characterized by tubercles of closely packed epithelioid cells, granulomas are the basic alteration in such chronic diseases as tuberculosis, leprosy, syphilis, sarcoidosis, deep fungus infections and in reactions to foreign material. These epithelioid cells are of reticulo-endothelial origin and may be regularly produced by the introduction of colloidal materials 1,2 Other than this, little is known concerning their origin. The present communication describes the production of a specific, hypersensitive, delayed reaction to zirconium which manifested itself as a granuloma.
ISSN:0028-0836
1476-4687
DOI:10.1038/1801060a0