Removal of Internally Deposited Radionuclides by Triethylenetetraamine-hexaacetic Acid

INCREASING the number of donor groups in chelating agents can give rise to the formation of more stable chelates 1–3 and, therefore, to a higher mobilization of internally deposited trivalent and other metal ions of higher valency. This has been demonstrated with ethylenediamine - NNN′N′ - tetraacet...

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Bibliographic Details
Published in:Nature (London) 1961-08, Vol.191 (4789), p.715-715
Main Authors: CATSCH, A, SCHINDEWOLF-JORDAN, D
Format: Article
Language:English
Subjects:
Chelating Agents - therapy
Humanities and Social Sciences
Humans
letter
multidisciplinary
Radiation Protection
Radioisotopes - metabolism
Science
Science (multidisciplinary)
Trientine
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Summary:INCREASING the number of donor groups in chelating agents can give rise to the formation of more stable chelates 1–3 and, therefore, to a higher mobilization of internally deposited trivalent and other metal ions of higher valency. This has been demonstrated with ethylenediamine - NNN′N′ - tetraacetic acid (EDTA) and diethylenetriamine-NNN′N′N″-penta-acetic acid (DTPA) 4,5 , that is, with chelating agents with 6 and 8 donor groups respectively. For this reason extension of this work to the 10-dentate triethylenetetraamine - NNN′ N′ N″ N‴ - hexaacetic acid (TTHA) seemed to be worth while.
ISSN:0028-0836
1476-4687
DOI:10.1038/191715a0