Inhibitory Action of Adenine, Adenine Nucleosides and Nucleotides on the Biosynthesis of Porphyrins by Rhodopseudomonas spheroides

OUR earlier investigations have shown that adenosine-5-monophosphoric acid (AMP) exerts a strong inhibitory action on excess porphyrin formation in rats with experimental porphyria 1,2 or in lead-poisoned rabbits 3 as well as in vitro during incubation of reticulocytes or liver homogenates of rabbit...

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Published in:Nature (London) 1963-09, Vol.199 (4898), p.1093-1094
Main Authors: GAJDOS, A, GAJDOS-TÖRÖK, M
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:OUR earlier investigations have shown that adenosine-5-monophosphoric acid (AMP) exerts a strong inhibitory action on excess porphyrin formation in rats with experimental porphyria 1,2 or in lead-poisoned rabbits 3 as well as in vitro during incubation of reticulocytes or liver homogenates of rabbits with glycine 4 . Rimington has also observed this effect of AMP in the porphyria induced in rats by hexachlorobenzene 5 . To obtain further results concerning this inhibition, we have investigated the effect of adenine, adenine nucleosides and nucleotides on the biosynthesis of porphyrins by Rhodopseudomonas spheroïdes . As it is known, this micro-organism synthesizes, in semi-anaerobic conditions and in the light, porphyrins (and bacteriochlorophyll) through the same biochemical mechanism as animal cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/1991093a0