Toxicity of Whole Tobacco Tar

AN experiment was designed to investigate the mortality pattern produced by large doses of tobacco tar in an inbred strain of mice. The object was to find the maximum dose that could evoke a definite carcinogenic response, without causing high mortality. An attempt was also made to investigate the p...

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Bibliographic Details
Published in:Nature (London) 1964-11, Vol.204 (4958), p.592-593
Main Author: FLAKS, ANTONIA
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
Mice
multidisciplinary
Neoplasms
Neoplasms, Experimental
Nicotiana
Pharmacology
Science
Science (multidisciplinary)
Skin Neoplasms
Tars
Toxicology
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Description
Summary:AN experiment was designed to investigate the mortality pattern produced by large doses of tobacco tar in an inbred strain of mice. The object was to find the maximum dose that could evoke a definite carcinogenic response, without causing high mortality. An attempt was also made to investigate the possibility of the development of tolerance to large doses of tobacco tar, by means of varied schedules of administration.
ISSN:0028-0836
1476-4687
DOI:10.1038/204592a0