Metabolic Effect of Epinephrine on the QO2 of the Arrested Isolated Perfused Rat Heart

SYMPATHETIC amines increase the oxygen consumption of the myocardium and it has usually been assumed that this is related primarily, if not exclusively, to the increase effected in rate and contractility. The present investigation demonstrates an increase in myocardial oxygen consumption due to epin...

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Bibliographic Details
Published in:Nature (London) 1965-01, Vol.205 (4971), p.602-603
Main Authors: CHALLONER, DAVID R., STEINBERG, DANIEL
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:SYMPATHETIC amines increase the oxygen consumption of the myocardium and it has usually been assumed that this is related primarily, if not exclusively, to the increase effected in rate and contractility. The present investigation demonstrates an increase in myocardial oxygen consumption due to epinephrine during potassium-induced cardiac arrest, that is, in the absence of any chronotropic or inotropic effect. This metabolic increase in oxygen consumption is accompanied by an increase in glycerol release into the perfusion medium, suggesting that the rate of utilization of endogenous lipids rises.
ISSN:0028-0836
1476-4687
DOI:10.1038/205602b0