Mechanism of Norepinephrine Binding

A NUMBER of sympathomimetic amines chemically related to norepinephrine (Fig. 1), which have either a catechol or β-hydroxyl group, can be stored in the vesicles of sympathetic nerves 1 . Octopamine, which lacks only the m -hydroxyl group of norepinephrine, is released by nerve stimulation 2 , and i...

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Bibliographic Details
Published in:Nature (London) 1965-02, Vol.205 (4971), p.606-607
Main Authors: MUSACCHIO, JOSE M, WEISE, VIRGINIA K, KOPIN, IRWIN J
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
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Summary:A NUMBER of sympathomimetic amines chemically related to norepinephrine (Fig. 1), which have either a catechol or β-hydroxyl group, can be stored in the vesicles of sympathetic nerves 1 . Octopamine, which lacks only the m -hydroxyl group of norepinephrine, is released by nerve stimulation 2 , and is depleted by drugs which deplete norepinephrine 3 . Although bound to particles with similar sedimentation characteristics as those which store norepinephrine 4,5 , octopamine appears to be stored mainly in a compartment which has a rapid turnover.
ISSN:0028-0836
1476-4687
DOI:10.1038/205606a0